C DRIVE RED LINING!

[Keyplayer]

I've got an ADK PC with a 1TB drive that's been partitioned into 2 500gb Sections, one of which is housing my O.S. That section is now in the red, saying that I've only got 28.6gb of free space left! Obviously this is not good and I've moved a lot of "lesser important" programs to other drives to free up more space. But I can't get it back down into a comfortable "breathing room (Blue)" zone. So, here's my question.

If I do a complete Paragon Backup of EVERYTHING on this drive onto a 1 or 2tb drive, could I then swap the drives and have the larger drive still run like an O.S. drive? Will that work, or am I going to have to rebuild a new O.S. drive from scratch?

All pertinent advice and/or alternative solutions welcomed. Thanks!

[Keyplayer]

It looks like the Paragon backup will suffice as a plug and play new :C drive. I can back up the 500gb section of the current :C drive onto my blank 2TB drive. Since conventional wisdom supports smaller sections for OS because of speed and other management issues, the question now is will I experience any drastic changes in OS functions by moving the OS over to the much larger drive?